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High fructose consumption results in pathological changes such as insulin resistance, dyslipidemia, and hypertension in rats resembling metabolic syndrome

Clinical trials, such as that by Falutz et al

287 Recent studies have shown that in obese individuals, increased fat is associated with iron homeostatic imbalance manifested as elevated ferritin, elevated serum hepcidin, and increased risk of iron overload

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The afferent input generated by formalin is believed to release excitatory amino acids and peptides as inflammatory signaling molecules, which, through NMDA and NK1 receptors, initiate a cascade